Elevated glucose and oligomeric [beta]-amyloid disrupt synapses via a common pathway of aberrant pro...
Elevated glucose and oligomeric [beta]-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
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London: Nature Publishing Group
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English
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Publisher
London: Nature Publishing Group
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Metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM) increase risk for Alzheimer's disease (AD). The molecular mechanism for this association remains poorly defined. Here we report in human and rodent tissues that elevated glucose, as found in MetS/T2DM, and oligomeric β-amyloid (Aβ) peptide, thought to be a key mediator of AD, coordinatel...
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Full title
Elevated glucose and oligomeric [beta]-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
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TN_cdi_proquest_journals_1754531650
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1754531650
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E-ISSN
2041-1723
DOI
10.1038/ncomms10242
