Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA
Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA
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Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Contents
Amyloid-like protein aggregation is associated with neurodegeneration and other pathologies. The nature of the toxic aggregate species and their mechanism of action remain elusive. Here, we analyzed the compartment specificity of aggregate toxicity using artificial β-sheet proteins, as well as fragments of mutant huntingtin and TAR DNA binding prot...
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Full title
Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA
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TN_cdi_proquest_journals_1756238508
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1756238508
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aad2033
