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Dysregulated YAP1/TAZ and TGF-[Beta] signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mi...

Dysregulated YAP1/TAZ and TGF-[Beta] signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mi...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1759028712

Dysregulated YAP1/TAZ and TGF-[Beta] signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice

About this item

Full title

Dysregulated YAP1/TAZ and TGF-[Beta] signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice

Publisher

Washington: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2016-01, Vol.113 (1), p.E71

Language

English

Formats

Publication information

Publisher

Washington: National Academy of Sciences

More information

Scope and Contents

Contents

Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b double deficiency in mouse liver (LMob1DKO) results in hyperplasia of oval cells and immature cholangiocytes accompanied by inflammatory cell infiltration and fibrosis. More than half of mutant...

Alternative Titles

Full title

Dysregulated YAP1/TAZ and TGF-[Beta] signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1759028712

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1759028712

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

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