Reduction of aberrant NF-[kappa]B signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
Reduction of aberrant NF-[kappa]B signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
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London: Nature Publishing Group
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English
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London: Nature Publishing Group
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Mutations in the transcriptional regulator Mecp2 cause the severe X-linked neurodevelopmental disorder Rett syndrome (RTT). In this study, we investigate genes that function downstream of MeCP2 in cerebral cortex circuitry, and identify upregulation of Irak1, a central component of the NF-κB pathway. We show that overexpression of Irak1 mimics the...
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Reduction of aberrant NF-[kappa]B signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice
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TN_cdi_proquest_journals_1761087152
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1761087152
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E-ISSN
2041-1723
DOI
10.1038/ncomms10520
