NF-[kappa]B activation impairs somatic cell reprogramming in ageing
NF-[kappa]B activation impairs somatic cell reprogramming in ageing
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Publisher
London: Nature Publishing Group
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Language
English
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Publisher
London: Nature Publishing Group
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Contents
Ageing constitutes a critical impediment to somatic cell reprogramming. We have explored the regulatory mechanisms that constitute age-associated barriers, through derivation of induced pluripotent stem cells (iPSCs) from individuals with premature or physiological ageing. We demonstrate that NF-κB activation blocks the generation of iPSCs in agein...
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Full title
NF-[kappa]B activation impairs somatic cell reprogramming in ageing
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TN_cdi_proquest_journals_1766136890
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1766136890
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3207
