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EGFR participates downstream of ER[alpha] in estradiol-17[beta]-d-glucuronide-induced impairment of...

EGFR participates downstream of ER[alpha] in estradiol-17[beta]-d-glucuronide-induced impairment of...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1771778809

EGFR participates downstream of ER[alpha] in estradiol-17[beta]-d-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets

About this item

Full title

EGFR participates downstream of ER[alpha] in estradiol-17[beta]-d-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets

Publisher

Heidelberg: Springer Nature B.V

Journal title

Archives of toxicology, 2016-04, Vol.90 (4), p.891

Language

English

Formats

Publication information

Publisher

Heidelberg: Springer Nature B.V

Subjects

More information

Scope and Contents

Contents

Estradiol-17[beta]-d-glucuronide (E17G) induces acute endocytic internalization of canalicular transporters, including multidrug resistance-associated protein 2 (Abcc2) in rat, generating cholestasis. Several proteins organized in at least two different signaling pathways are involved in E17G cholestasis: one pathway involves estrogen receptor alph...

Alternative Titles

Full title

EGFR participates downstream of ER[alpha] in estradiol-17[beta]-d-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1771778809

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1771778809

Other Identifiers

ISSN

0340-5761

E-ISSN

1432-0738

DOI

10.1007/s00204-015-1507-8

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