Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for ci...
Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The suprachiasmatic nucleus (SCN) defines 24 h of time via a transcriptional/posttranslational feedback loop in which transactivation of Per (period) and Cry (cryptochrome) genes by BMAL1–CLOCK complexes is suppressed by PER–CRY complexes. The molecular/structural basis of how circadian protein complexes function is poorly understood. We describe a...
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Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking
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TN_cdi_proquest_journals_1774333006
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1774333006
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1517549113
