Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling
Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling
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Publisher
England: BMJ Publishing Group Ltd and European League Against Rheumatism
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Language
English
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Publisher
England: BMJ Publishing Group Ltd and European League Against Rheumatism
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Contents
Objectives Canonical Wnt signalling has recently emerged as a key mediator of fibroblast activation and tissue fibrosis in systemic sclerosis. Here, we investigated tankyrases as novel molecular targets for inhibition of canonical Wnt signalling in fibrotic diseases. Methods The antifibrotic effects of the tankyrase inhibitor XAV-939 or of siRNA-me...
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Full title
Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling
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TN_cdi_proquest_journals_1777885095
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1777885095
Other Identifiers
ISSN
0003-4967
E-ISSN
1468-2060
DOI
10.1136/annrheumdis-2012-202275
