Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by...
Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Probing a wide range of cellular phenotypes in neurodevelopmental disorders using patient-derived neural progenitor cells (NPCs) can be facilitated by 3D assays, as 2D systems cannot entirely recapitulate the arrangement of cells in the brain. Here, we developed a previously unidentified 3D migration and differentiation assay in layered hydrogels t...
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Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction
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TN_cdi_proquest_journals_1780547563
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1780547563
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1521255113
