Tumor suppressor WWOX binds to [Delta]Np63[alpha] and sensitizes cancer cells to chemotherapy
Tumor suppressor WWOX binds to [Delta]Np63[alpha] and sensitizes cancer cells to chemotherapy
About this item
Full title
Author / Creator
Salah, Z , Bar-mag, T , Kohn, Y , Pichiorri, F , Palumbo, T , Melino, G and Aqeilan, R I
Publisher
London: Springer Nature B.V
Journal title
Language
English
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Publication information
Publisher
London: Springer Nature B.V
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Scope and Contents
Contents
The WWOX tumor suppressor is a WW domain-containing protein. Its function in the cell has been shown to be mediated, in part, by interacting with its partners through its first WW (WW1) domain. Here, we demonstrated that WWOX via WW1 domain interacts with p53 homolog, ΔNp63α. This protein-protein interaction stabilizes ΔNp63α, through antagonizing...
Alternative Titles
Full title
Tumor suppressor WWOX binds to [Delta]Np63[alpha] and sensitizes cancer cells to chemotherapy
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1786141849
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1786141849
Other Identifiers
E-ISSN
2041-4889
DOI
10.1038/cddis.2013.6
