984. Liver Restricted Expression of Canine Iduronidase Does Not Prevent a CTL Response in Adult MPS...
984. Liver Restricted Expression of Canine Iduronidase Does Not Prevent a CTL Response in Adult MPS I Mice after Retroviral Vector-Mediated Gene Therapy, but Transient Immunomodulation with CTLA4-Ig Combined with Anti-CD4 or Anti- CD40 Ligand Does
About this item
Full title
Author / Creator
Publisher
Milwaukee: Elsevier Limited
Journal title
Language
English
Formats
Publication information
Publisher
Milwaukee: Elsevier Limited
Subjects
More information
Scope and Contents
Contents
Mucopolysaccharidosis I (MPS I) is due to deficient activity of the 70 KD lysosomal enzyme α-L-iduronidase (IDUA) and results in an inability to degrade glycosaminoglycans in many cells. Severe MPS I results in cardiac disease, skeletal deformities, hearing and vision abnormalities, and mental retardation. We have previously reported that neonatal...
Alternative Titles
Full title
984. Liver Restricted Expression of Canine Iduronidase Does Not Prevent a CTL Response in Adult MPS I Mice after Retroviral Vector-Mediated Gene Therapy, but Transient Immunomodulation with CTLA4-Ig Combined with Anti-CD4 or Anti- CD40 Ligand Does
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1792798965
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1792798965
Other Identifiers
ISSN
1525-0016
E-ISSN
1525-0024
DOI
10.1016/j.ymthe.2006.08.1077
