Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the [beta]-Globin Locus Control...
Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the [beta]-Globin Locus Control Region
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Publisher
Milwaukee: Elsevier Limited
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Language
English
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Publisher
Milwaukee: Elsevier Limited
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Scope and Contents
Contents
Insertional mutagenesis by long terminal repeat (LTR) enhancers in γ-retrovirus-based vectors (GVs) in clinical trials has prompted deeper investigations into vector genotoxicity. Experimentally, self-inactivating (SIN) lentivirus vectors (LVs) and GV containing internal promoters/enhancers show reduced genotoxicity, although strong ubiquitously-ac...
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Full title
Genotoxic Potential of Lineage-specific Lentivirus Vectors Carrying the [beta]-Globin Locus Control Region
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TN_cdi_proquest_journals_1792808935
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1792808935
Other Identifiers
ISSN
1525-0016
E-ISSN
1525-0024
DOI
10.1038/mt.2009.183
