Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astro...
Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia
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Author / Creator
Demir, Ihsan Ekin , Tieftrunk, Elke , Schorn, Stephan , Saricaoglu, Ömer Cemil , Pfitzinger, Paulo L , Teller, Steffen , Wang, Kun , Waldbaur, Christine , Kurkowski, Magdalena U , Wörmann, Sonja Maria , Shaw, Victoria E , Kehl, Timo , Laschinger, Melanie , Costello, Eithne , Algül, Hana , Friess, Helmut and Ceyhan, Güralp O
Publisher
England: BMJ Publishing Group LTD
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Language
English
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Publisher
England: BMJ Publishing Group LTD
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Contents
ObjectiveThe impact of glia cells during GI carcinogenesis and in cancer pain is unknown. Here, we demonstrate a novel mechanism how Schwann cells (SCs) become activated in the pancreatic cancer (PCa) microenvironment and influence spinal activity and pain sensation.DesignHuman SCs were exposed to hypoxia, to pancreatic cancer cells (PCCs) and/or t...
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Full title
Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia
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TN_cdi_proquest_journals_1793871825
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1793871825
Other Identifiers
ISSN
0017-5749
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2015-309784
