Design of an [alpha]-helical antimicrobial peptide with improved cell-selective and potent anti-biof...
Design of an [alpha]-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity
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London: Nature Publishing Group
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English
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London: Nature Publishing Group
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AR-23 is a melittin-related peptide with 23 residues. Like melittin, its high α-helical amphipathic structure results in strong bactericidal activity and cytotoxicity. In this study, a series of AR-23 analogues with low amphipathicity were designed by substitution of Ala1, Ala8 and Ile17 with positively charged residues (Arg or Lys) to study the ef...
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Design of an [alpha]-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity
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TN_cdi_proquest_journals_1794558035
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1794558035
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E-ISSN
2045-2322
DOI
10.1038/srep27394
