Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helpless...
Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helplessness
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Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Rationale
Pharmacological and genetic evidence support antidepressant-like effects elicited by the blockade of the NOP receptor. The learned helplessness (LH) model employs uncontrollable and unpredictable electric footshocks as a stressor stimulus to induce a depressive-like phenotype that can be reversed by classical antidepressants.
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Full title
Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helplessness
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TN_cdi_proquest_journals_1796448431
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1796448431
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ISSN
0033-3158
E-ISSN
1432-2072
DOI
10.1007/s00213-016-4310-1
