MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function
MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function
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Author / Creator
Brauer, R , Tureckova, J , Kanchev, I , Khoylou, M , Skarda, J , Prochazka, J , Spoutil, F , Beck, I M , Zbodakova, O , Kasparek, P , Korinek, V , Chalupsky, K , Karhu, T , Herzig, K-H , Hajduch, M , Gregor, M and Sedlacek, R
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Matrix metalloproteinases (MMPs) are potential biomarkers for disease activity in inflammatory bowel disease (IBD). However, clinical trials targeting MMPs have not succeeded, likely due to poor understanding of the biological functions of individual MMPs. Here, we explore the role of MMP-19 in IBD pathology. Using a DSS-induced model of colitis, w...
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Full title
MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function
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TN_cdi_proquest_journals_1798267026
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1798267026
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ISSN
1933-0219
E-ISSN
1935-3456
DOI
10.1038/mi.2015.117
