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Multilineage transduction of resident lung cells in vivo by AAV2/8 for [alpha]1-antitrypsin gene the...

Multilineage transduction of resident lung cells in vivo by AAV2/8 for [alpha]1-antitrypsin gene the...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1800270990

Multilineage transduction of resident lung cells in vivo by AAV2/8 for [alpha]1-antitrypsin gene therapy

About this item

Full title

Multilineage transduction of resident lung cells in vivo by AAV2/8 for [alpha]1-antitrypsin gene therapy

Publisher

Milwaukee: Elsevier Limited

Journal title

Molecular therapy. Methods & clinical development, 2016-06, Vol.3, p.16042

Language

English

Formats

Publication information

Publisher

Milwaukee: Elsevier Limited

More information

Scope and Contents

Contents

In vivo gene delivery has long represented an appealing potential treatment approach for monogenic diseases such as α1 -antitrypsin deficiency (AATD) but has proven challenging to achieve in practice. Alternate pseudotyping of recombinant adeno-associated virus (AAV) vectors is producing vectors with increasingly heterogeneous tropic specificity, g...

Alternative Titles

Full title

Multilineage transduction of resident lung cells in vivo by AAV2/8 for [alpha]1-antitrypsin gene therapy

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1800270990

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1800270990

Other Identifiers

E-ISSN

2329-0501

DOI

10.1038/mtm.2016.42

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