Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN...
Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation
About this item
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Author / Creator
Zheng, Jian , Huang, Xudong , Tan, Wen , Yu, Dianke , Du, Zhongli , Chang, Jiang , Wei, Lixuan , Han, Yaling , Wang, Chengfeng , Che, Xu , Zhou, Yifeng , Miao, Xiaoping , Jiang, Guoliang , Yu, Xianjun , Yang, Xianghong , Cao, Guangwen , Zuo, Chaohui , Li, Zhaoshen , Wang, Chunyou , Cheung, Siu Tim , Jia, Yongfeng , Zheng, Xiongwei , Shen, Hongbing , Wu, Chen and Lin, Dongxin
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Dongxin Lin, Chen Wu and colleagues identify a
LINC00673
variant that associates with pancreatic cancer risk in Han Chinese cohorts. They show that the variant creates a target site for miR-1231 and that LINC00673 regulates PTPN11 degradation and leads to altered SRC–ERK and STAT1-dependent signaling.
Genome-wide association studies have i...
Alternative Titles
Full title
Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation
Authors, Artists and Contributors
Author / Creator
Huang, Xudong
Tan, Wen
Yu, Dianke
Du, Zhongli
Chang, Jiang
Wei, Lixuan
Han, Yaling
Wang, Chengfeng
Che, Xu
Zhou, Yifeng
Miao, Xiaoping
Jiang, Guoliang
Yu, Xianjun
Yang, Xianghong
Cao, Guangwen
Zuo, Chaohui
Li, Zhaoshen
Wang, Chunyou
Cheung, Siu Tim
Jia, Yongfeng
Zheng, Xiongwei
Shen, Hongbing
Wu, Chen
Lin, Dongxin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1801624783
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1801624783
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3568
