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Targeting renal cell carcinoma with a HIF-2 antagonist

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Targeting renal cell carcinoma with a HIF-2 antagonist

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1838071737

Targeting renal cell carcinoma with a HIF-2 antagonist

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Publisher

London: Nature Publishing Group

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Scope and Contents

Contents

Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL)1,2. Because no other gene is mutated as frequently in ccRCC and VHL mutations are truncal3, VHL inactivation is regarded as the governing event4. VHL loss activates the HIF-2 transcription factor, and constitutive HIF-2 act...

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Full title

Targeting renal cell carcinoma with a HIF-2 antagonist

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Record Identifier

TN_cdi_proquest_journals_1838071737

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1838071737

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/naturel9796

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