Targeting PPAR[gamma] in the epigenome rescues genetic metabolic defects in mice
Targeting PPAR[gamma] in the epigenome rescues genetic metabolic defects in mice
About this item
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Author / Creator
Soccio, Raymond E , Li, Zhenghui , Chen, Eric R , Foong, Yee Hoon , Benson, Kiara K , Dispirito, Joanna R , Mullican, Shannon E , Emmett, Matthew J , Briggs, Erika R , Peed, Lindsey C , Dzeng, Richard K , Medina, Carlos J , Jolivert, Jennifer F , Kissig, Megan , Rajapurkar, Satyajit R , Damle, Manashree , Lim, Hee-Woong , Won, Kyoung-Jae , Seale, Patrick , Steger, David J and Lazar, Mitchell A
Publisher
Ann Arbor: American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
Ann Arbor: American Society for Clinical Investigation
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More information
Scope and Contents
Contents
Obesity causes insulin resistance, and PPAR[gamma] ligands such as rosiglitazone are insulin sensitizing, yet the mechanisms remain unclear. In C57BL/6 (B6) mice, obesity induced by a high-fat diet (HFD) has major effects on visceral epididymal adipose tissue (eWAT). Here, we report that HFD-induced obesity in B6 mice also altered the activity of g...
Alternative Titles
Full title
Targeting PPAR[gamma] in the epigenome rescues genetic metabolic defects in mice
Authors, Artists and Contributors
Author / Creator
Li, Zhenghui
Chen, Eric R
Foong, Yee Hoon
Benson, Kiara K
Dispirito, Joanna R
Mullican, Shannon E
Emmett, Matthew J
Briggs, Erika R
Peed, Lindsey C
Dzeng, Richard K
Medina, Carlos J
Jolivert, Jennifer F
Kissig, Megan
Rajapurkar, Satyajit R
Damle, Manashree
Lim, Hee-Woong
Won, Kyoung-Jae
Seale, Patrick
Steger, David J
Lazar, Mitchell A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1892737423
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1892737423
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI91211
