RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of A[bet...
RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of A[beta] oligomers
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London: Nature Publishing Group
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English
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London: Nature Publishing Group
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Bexarotene, a selective agonist for Retinoid X receptors (RXR) improves cognitive deficits and amyloid-β (Aβ) clearance in mice. Here we examine if the effect of bexarotene on RXR cistrome and transcriptomes depend on APOE isoform and Aβ deposition. We found bexarotene increased RXR binding to promoter regions in cortex of APOE3 mice. Rho family GT...
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RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of A[beta] oligomers
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TN_cdi_proquest_journals_1898677840
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1898677840
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E-ISSN
2045-2322
DOI
10.1038/srep24048
