Metabolite monitoring to guide thiopurine therapy in systemic autoimmune diseases
Metabolite monitoring to guide thiopurine therapy in systemic autoimmune diseases
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Publisher
London: Springer London
Journal title
Language
English
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Publisher
London: Springer London
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Contents
6-Thioguanine nucleotide (6-TGN) is the active metabolite of thiopurine drugs azathioprine and 6-mercaptopurine. 6-Methylmercaptopurine (6-MMP) is an inactive and potentially hepatotoxic metabolite. A subgroup of patients (shunters) preferentially produce 6-MMP instead of 6-TGN, therefore displaying thiopurine resistance and risk for hepatotoxicity...
Alternative Titles
Full title
Metabolite monitoring to guide thiopurine therapy in systemic autoimmune diseases
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TN_cdi_proquest_journals_1904774004
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1904774004
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ISSN
0770-3198
E-ISSN
1434-9949
DOI
10.1007/s10067-017-3554-4
