HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downre...
HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway
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Athens: D.A. Spandidos
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Language
English
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Athens: D.A. Spandidos
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Contents
Multidrug resistance (MDR) plays a pivotal role in human chronic myelogenous leukemia (CML) chemotherapy failure. MDR is mainly associated with the overexpression of drug efflux transporters of the ATP-binding cassette (ABC) proteins. Phosphoinositide 3-kinase (PI3K)/Akt signaling cascade is involved in the MDR phenotype and is correlated with mult...
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Full title
HOXB4 knockdown reverses multidrug resistance of human myelogenous leukemia K562/ADM cells by downregulating P-gp, MRP1 and BCRP expression via PI3K/Akt signaling pathway
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TN_cdi_proquest_journals_1932309068
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1932309068
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ISSN
1019-6439
E-ISSN
1791-2423
DOI
10.3892/ijo.2016.3738
