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Imidazole inhibits autophagy flux by blocking autophagic degradation and triggers apoptosis via incr...

Imidazole inhibits autophagy flux by blocking autophagic degradation and triggers apoptosis via incr...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1932313483

Imidazole inhibits autophagy flux by blocking autophagic degradation and triggers apoptosis via increasing FoxO3a-Bim expression

About this item

Full title

Imidazole inhibits autophagy flux by blocking autophagic degradation and triggers apoptosis via increasing FoxO3a-Bim expression

Publisher

Athens: D.A. Spandidos

Journal title

International journal of oncology, 2015-02, Vol.46 (2), p.721-731

Language

English

Formats

Publication information

Publisher

Athens: D.A. Spandidos

More information

Scope and Contents

Contents

Imidazole, an organic alkaloid, is an important pharmacophore in drug discovery. Anti-neoplastic potential of imidazole derivatives has been documented in several studies; however, mechanisms by which tumor cells respond to these stimuli remain to be elucidated. Autophagy and apoptosis have key roles in tumorigenesis and tumor treatment. In this st...

Alternative Titles

Full title

Imidazole inhibits autophagy flux by blocking autophagic degradation and triggers apoptosis via increasing FoxO3a-Bim expression

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1932313483

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1932313483

Other Identifiers

ISSN

1019-6439

E-ISSN

1791-2423

DOI

10.3892/ijo.2014.2771

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