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Downregulation of Nrf2 promotes radiation-induced apoptosis through Nrf2 mediated Notch signaling in...

Downregulation of Nrf2 promotes radiation-induced apoptosis through Nrf2 mediated Notch signaling in...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1932325960

Downregulation of Nrf2 promotes radiation-induced apoptosis through Nrf2 mediated Notch signaling in non-small cell lung cancer cells

About this item

Full title

Downregulation of Nrf2 promotes radiation-induced apoptosis through Nrf2 mediated Notch signaling in non-small cell lung cancer cells

Publisher

Athens: D.A. Spandidos

Journal title

International journal of oncology, 2016-02, Vol.48 (2), p.765-773

Language

English

Formats

Publication information

Publisher

Athens: D.A. Spandidos

More information

Scope and Contents

Contents

The nuclear factor erythroid-2-related factor 2 (Nrf2) is a crucial regulator of the cellular antioxidant system. Nrf2 is often constitutively activated in non-small cell lung cancer (NSCLC) cell lines, which promotes cytoprotection against oxidative stress and xenobiotics. Notch1 signaling is critically implicated in cell fate determination. It ha...

Alternative Titles

Full title

Downregulation of Nrf2 promotes radiation-induced apoptosis through Nrf2 mediated Notch signaling in non-small cell lung cancer cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1932325960

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1932325960

Other Identifiers

ISSN

1019-6439

E-ISSN

1791-2423

DOI

10.3892/ijo.2015.3301

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