Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
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Author / Creator
Ve, Thomas , Vajjhala, Parimala R , Hedger, Andrew , Croll, Tristan , DiMaio, Frank , Horsefield, Shane , Yu, Xiong , Lavrencic, Peter , Hassan, Zahid , Morgan, Garry P , Mansell, Ashley , Mobli, Mehdi , O'Carroll, Ailis , Chauvin, Brieuc , Gambin, Yann , Sierecki, Emma , Landsberg, Michael J , Stacey, Katryn J , Egelman, Edward H and Kobe, Bostjan
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Structural insight into TIR-domain interactions, which are essential for the recruitment of signaling adapters to Toll-like receptors during innate immune responses, demonstrates a conserved interaction mode involved in both TLR and IL-1R signaling.
Toll-like receptor (TLR) signaling is a key innate immunity response to pathogens. Recruitment of...
Alternative Titles
Full title
Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
Authors, Artists and Contributors
Author / Creator
Vajjhala, Parimala R
Hedger, Andrew
Croll, Tristan
DiMaio, Frank
Horsefield, Shane
Yu, Xiong
Lavrencic, Peter
Hassan, Zahid
Morgan, Garry P
Mansell, Ashley
Mobli, Mehdi
O'Carroll, Ailis
Chauvin, Brieuc
Gambin, Yann
Sierecki, Emma
Landsberg, Michael J
Stacey, Katryn J
Egelman, Edward H
Kobe, Bostjan
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Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1936272308
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1936272308
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3444
