Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing
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Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Lipolysis declines with age because NLRP3 inflammasome-activated adipose tissue macrophages reduce levels of noradrenaline by upregulating genes that control its degradation, such as
GDF3
and
MAOA
.
The age old problem of fat breakdown
With increasing age, lipolysis (the breakdown of fats in the body) induced by catecholamines dec...
Alternative Titles
Full title
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing
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TN_cdi_proquest_journals_1948347641
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1948347641
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature24022
