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TGF-[beta]-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhib...

TGF-[beta]-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhib...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_195250906

TGF-[beta]-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

About this item

Full title

TGF-[beta]-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

Publisher

New York: Springer Nature B.V

Journal title

The EMBO journal, 2001-05, Vol.20 (9), p.2254

Language

English

Formats

Publication information

Publisher

New York: Springer Nature B.V

More information

Scope and Contents

Contents

Transforming growth factor-[beta] (TGF-[beta]), a secreted factor present at high levels in bone, inhibits osteoblast differentiation in culture; yet, the mechanism of this inhibition remains unclear. We studied the effects of TGF-[beta] and its effectors, the Smads, on the expression and function of the osteoblast transcription factor CBFA1. TGF-[...

Alternative Titles

Full title

TGF-[beta]-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_195250906

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_195250906

Other Identifiers

ISSN

0261-4189

E-ISSN

1460-2075

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