Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1[beta] release through pyrop...
Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1[beta] release through pyrophosphates
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New York: Springer Nature B.V
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English
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New York: Springer Nature B.V
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In acute inflammation, extracellular ATP activates P2X(7) ion channel receptors (P2X(7)R) on M1 polarized macrophages to release pro-inflammatory IL-1beta through activation of the caspase-1/nucleotide-binding domain and leucine-rich repeat receptor containing pyrin domain 3 (NLRP3) inflammasome. In contrast, M2 polarized macrophages are critical t...
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Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1[beta] release through pyrophosphates
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TN_cdi_proquest_journals_195260834
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_195260834
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ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2009.163
