Morphine induces terminal [mu]-opioid receptor desensitization by sustained phosphorylation of serin...
Morphine induces terminal [mu]-opioid receptor desensitization by sustained phosphorylation of serine-375
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Publisher
New York: Springer Nature B.V
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Language
English
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Publisher
New York: Springer Nature B.V
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Contents
Morphine is a poor inducer of micro-opioid receptor (MOR) internalization, but a potent inducer of cellular tolerance. Here we show that, in contrast to full agonists such as [D-Ala(2)-MePhe(4)-Gly-ol]enkephalin (DAMGO), morphine stimulated a selective phosphorylation of the carboxy-terminal residue 375 (Ser(375)). Ser(375) phosphorylation was suff...
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Full title
Morphine induces terminal [mu]-opioid receptor desensitization by sustained phosphorylation of serine-375
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TN_cdi_proquest_journals_195265552
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_195265552
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ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/sj.emboj.7600334
