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Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase [beta]

Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase [beta]

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_195269476

Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase [beta]

About this item

Full title

Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase [beta]

Publisher

New York: Springer Nature B.V

Journal title

The EMBO journal, 2000-03, Vol.19 (6), p.1397

Language

English

Formats

Publication information

Publisher

New York: Springer Nature B.V

Subjects

Subjects and topics

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Scope and Contents

Contents

DNA polymerase [beta] (Pol[beta]) has been implicated in base excision repair in mammalian cells. However, the physiological significance of this enzyme in the body remains unclear. Here, we demonstrate that mice carrying a targeted disruption of the Pol[beta] gene showed growth retardation and died of a respiratory failure immediately after the bi...

Alternative Titles

Full title

Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase [beta]

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Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_195269476

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_195269476

Other Identifiers

ISSN

0261-4189

E-ISSN

1460-2075

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