Standard codon substitution models overestimate purifying selection for non-stationary data
Standard codon substitution models overestimate purifying selection for non-stationary data
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San Diego: PeerJ, Inc
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English
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San Diego: PeerJ, Inc
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Estimation of natural selection on protein-coding sequences is a key comparative genomics approach for de novo prediction of lineage specific adaptations. Selective pressure is measured on a per-gene basis by comparing the rate of non-synonymous substitutions to the rate of neutral evolution, typically assumed to be the rate of synonymous substitut...
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Standard codon substitution models overestimate purifying selection for non-stationary data
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TN_cdi_proquest_journals_1953937443
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1953937443
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E-ISSN
2167-9843
DOI
10.7287/peerj.preprints.2218v1
