Simvastatin inhibits the expression of stemness-related genes and the metastatic invasion of human c...
Simvastatin inhibits the expression of stemness-related genes and the metastatic invasion of human cancer cells via destruction of the cytoskeleton
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Athens: D.A. Spandidos
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Language
English
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Athens: D.A. Spandidos
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Contents
Statins are a class of drugs that inhibit the rate-limiting steps in the cholesterol biosynthesis pathway. They act by inhibiting 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate. Blocking of mevalonate synthesis leads to inhibition of the farnesylation and geranylgeranylation of several fu...
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Full title
Simvastatin inhibits the expression of stemness-related genes and the metastatic invasion of human cancer cells via destruction of the cytoskeleton
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TN_cdi_proquest_journals_1986664771
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1986664771
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ISSN
1019-6439
E-ISSN
1791-2423
DOI
10.3892/ijo.2017.4158
