BC-02 eradicates liver cancer stem cells by upregulating the ROS-dependent DNA damage
BC-02 eradicates liver cancer stem cells by upregulating the ROS-dependent DNA damage
About this item
Full title
Author / Creator
Dou, Chunhui , Fang, Chunyan , Zhao, Yan , Fu, Xiaoyan , Zhang, Yufei , Zhu, Dongqi , Wu, Huina , Liu, Huijie , Zhang, Jian , Xu, Wenfang , Liu, Zhijun , Wang, Hongyan , Li, Daqi and Wang, Xuejian
Publisher
Athens: D.A. Spandidos
Journal title
Language
English
Formats
Publication information
Publisher
Athens: D.A. Spandidos
Subjects
More information
Scope and Contents
Contents
Cancer stem cells (CSCs) are responsible for chemoresistance, tumor recurrence and metastasis. Reportedly, aminopeptidase N (APN, also known as CD13) is a marker for semi-quiescent CSCs and a therapeutic target in human liver CSCs. In the present study, the effect of BC-02, a compound obtained by conjugating a CD13 inhibitor bestatin and fluorourac...
Alternative Titles
Full title
BC-02 eradicates liver cancer stem cells by upregulating the ROS-dependent DNA damage
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1986665625
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1986665625
Other Identifiers
ISSN
1019-6439
E-ISSN
1791-2423
DOI
10.3892/ijo.2017.4159
