Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggre...
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation
About this item
Full title
Author / Creator
Naumann, Marcel , Pal, Arun , Goswami, Anand , Lojewski, Xenia , Japtok, Julia , Vehlow, Anne , Naujock, Maximilian , Günther, René , Jin, Mengmeng , Stanslowsky, Nancy , Reinhardt, Peter , Sterneckert, Jared , Frickenhaus, Marie , Pan-Montojo, Francisco , Storkebaum, Erik , Poser, Ina , Freischmidt, Axel , Weishaupt, Jochen H. , Holzmann, Karlheinz , Troost, Dirk , Ludolph, Albert C. , Boeckers, Tobias M. , Liebau, Stefan , Petri, Susanne , Cordes, Nils , Hyman, Anthony A. , Wegner, Florian , Grill, Stephan W. , Weis, Joachim , Storch, Alexander and Hermann, Andreas
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Amyotrophic lateral sclerosis (ALS) is the most frequent motor neuron disease. Cytoplasmic fused in sarcoma (FUS) aggregates are pathological hallmarks of FUS-ALS. Proper shuttling between the nucleus and cytoplasm is essential for physiological cell function. However, the initial event in the pathophysiology of FUS-ALS remains enigmatic. Using hum...
Alternative Titles
Full title
Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation
Authors, Artists and Contributors
Author / Creator
Pal, Arun
Goswami, Anand
Lojewski, Xenia
Japtok, Julia
Vehlow, Anne
Naujock, Maximilian
Günther, René
Jin, Mengmeng
Stanslowsky, Nancy
Reinhardt, Peter
Sterneckert, Jared
Frickenhaus, Marie
Pan-Montojo, Francisco
Storkebaum, Erik
Poser, Ina
Freischmidt, Axel
Weishaupt, Jochen H.
Holzmann, Karlheinz
Troost, Dirk
Ludolph, Albert C.
Boeckers, Tobias M.
Liebau, Stefan
Petri, Susanne
Cordes, Nils
Hyman, Anthony A.
Wegner, Florian
Grill, Stephan W.
Weis, Joachim
Storch, Alexander
Hermann, Andreas
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_1990472747
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1990472747
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02299-1
