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Structure-based drug design, synthesis and biological assays of P. falciparum Atg3–Atg8 protein–prot...

Structure-based drug design, synthesis and biological assays of P. falciparum Atg3–Atg8 protein–prot...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1993585097

Structure-based drug design, synthesis and biological assays of P. falciparum Atg3–Atg8 protein–protein interaction inhibitors

About this item

Full title

Structure-based drug design, synthesis and biological assays of P. falciparum Atg3–Atg8 protein–protein interaction inhibitors

Publisher

Cham: Springer International Publishing

Journal title

Journal of computer-aided molecular design, 2018-03, Vol.32 (3), p.473-486

Language

English

Formats

Publication information

Publisher

Cham: Springer International Publishing

More information

Scope and Contents

Contents

The proteins involved in the autophagy (Atg) pathway have recently been considered promising targets for the development of new antimalarial drugs. In particular, inhibitors of the protein–protein interaction (PPI) between Atg3 and Atg8 of
Plasmodium falciparum
retarded the blood- and liver-stages of parasite growth. In this paper, we used co...

Alternative Titles

Full title

Structure-based drug design, synthesis and biological assays of P. falciparum Atg3–Atg8 protein–protein interaction inhibitors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_1993585097

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_1993585097

Other Identifiers

ISSN

0920-654X

E-ISSN

1573-4951

DOI

10.1007/s10822-018-0102-5

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