Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB
Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Cellular movement is controlled by small GTPases, such as RhoA. Although migration is crucial for cancer cell invasion, the specific role of RhoA in tumor formation is unclear. Inducing skin tumors in mice with a keratinocyte-restricted loss of RhoA, we observed increased tumor frequency, growth and invasion.
In vitro
invasion assays revealed...
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Full title
Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB
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TN_cdi_proquest_journals_2002186043
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2002186043
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2017.333
