Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
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United States: The American Association for the Advancement of Science
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English
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United States: The American Association for the Advancement of Science
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Permeability glycoprotein (PgP) uses the energy from adenosine triphosphate (ATP) hydrolysis to transport substrates out of the cell. Many of its substrates are drugs, so it plays an important role in drug resistance. Structures in the inward-facing conformation have been determined for mouse, yeast, and algal PgP. Kim and Chen present the cryo–ele...
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Full title
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
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TN_cdi_proquest_journals_2007528139
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2007528139
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aar7389
