IL-1ß enables CNS access to CCR2hi monocytes and the generation of pathogenic cells through GM-CSF r...
IL-1ß enables CNS access to CCR2hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells
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Washington: National Academy of Sciences
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Language
English
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Washington: National Academy of Sciences
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Molecular interventions that limit pathogenic CNS inflammation are used to treat autoimmune conditions such as multiple sclerosis (MS). Remarkably, IL-1β-knockout mice are highly resistant to experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Here, we show that interfering with the IL-1β/IL-1R1 axis severely impairs the transmi...
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IL-1ß enables CNS access to CCR2hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells
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TN_cdi_proquest_journals_2008894134
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2008894134
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ISSN
0027-8424
E-ISSN
1091-6490
