Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell car...
Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas
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Author / Creator
Whitson, Ramon J , Lee, Alex , Urman, Nicole M , Mirza, Amar , Yao, Catherine Y , Brown, Alexander S , Li, Jiang R , Shankar, Gautam , Fry, Micah A , Atwood, Scott X , Lee, Eunice Y , Hollmig, S Tyler , Aasi, Sumaira Z , Sarin, Kavita Y , Scott, Matthew P , Epstein, Ervin H , Tang, Jean Y and Oro, Anthony E
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
A large proportion of basal cell carcinomas develop resistance independently of the canonical mutations in genes encoding hedgehog pathway components. An unbiased analysis investigating alternative pathways of resistance uncovers the role of cytoskeletal signaling in driving noncanonical activation of hedgehog signaling through nuclear translocatio...
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Full title
Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas
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TN_cdi_proquest_journals_2011289268
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2011289268
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4476