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Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell car...

Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell car...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2011289268

Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas

About this item

Full title

Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas

Publisher

New York: Nature Publishing Group US

Journal title

Nature medicine, 2018-03, Vol.24 (3), p.271-281

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

A large proportion of basal cell carcinomas develop resistance independently of the canonical mutations in genes encoding hedgehog pathway components. An unbiased analysis investigating alternative pathways of resistance uncovers the role of cytoskeletal signaling in driving noncanonical activation of hedgehog signaling through nuclear translocatio...

Alternative Titles

Full title

Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_2011289268

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2011289268

Other Identifiers

ISSN

1078-8956

E-ISSN

1546-170X

DOI

10.1038/nm.4476

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