Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5–C...
Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5–C16 degradation fragment of reidispongiolide A
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United States: National Acad Sciences
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Language
English
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United States: National Acad Sciences
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Reidispongiolide A is a representative member of the sphinxolide/reidispongiolide group of cytotoxic 26-membered macrolides of marine origin. By interacting with actin in the cell cytoskeleton, the reidispongiolides and sphinxolides are potent microfilament destabilizing agents that represent a promising mechanism of action for developing novel ant...
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Full title
Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5–C16 degradation fragment of reidispongiolide A
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TN_cdi_proquest_journals_201290025
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201290025
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0401548101
