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MTHFR 677C ¡ genotype disrupts prefrontal function in schizophrenia through an interaction with COMT...

MTHFR 677C ¡ genotype disrupts prefrontal function in schizophrenia through an interaction with COMT...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201310718

MTHFR 677C ¡ genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val ¡ Met

About this item

Full title

MTHFR 677C ¡ genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val ¡ Met

Publisher

Washington: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2008-11, Vol.105 (45), p.17573

Language

English

Formats

Publication information

Publisher

Washington: National Academy of Sciences

More information

Scope and Contents

Contents

Understanding how risk genes cumulatively impair brain function in schizophrenia could provide critical insights into its pathophysiology. Working memory impairment in schizophrenia has been associated with abnormal dopamine signaling in the prefrontal cortex, which is likely under complex genetic control. The catechol-O-methyltransferase (COMT) 15...

Alternative Titles

Full title

MTHFR 677C ¡ genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val ¡ Met

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_201310718

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201310718

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

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