Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore
Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore
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Author / Creator
Severin, Fedor F , Severina, Inna I , Antonenko, Yury N , Rokitskaya, Tatiana I , Cherepanov, Dmitry A , Mokhova, Elena N , Vyssokikh, Mikhail Yu , Pustovidko, Antonina V , Markova, Olga V , Yaguzhinsky, Lev S , Korshunova, Galina A , Sumbatyan, Nataliya V , Skulachev, Maxim V and Skulachev, Vladimir P
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
A unique phenomenon of mitochondria-targeted protonophores is described. It consists in a transmembrane H⁺-conducting fatty acid cycling mediated by penetrating cations such as 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) or dodecyltriphenylphosphonium (C₁₂TPP). The phenomenon has been modeled by molecular dynamics and directly proved by...
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Full title
Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore
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Record Identifier
TN_cdi_proquest_journals_201328195
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201328195
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0910216107
