P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
The pathway involving the tumor suppressor gene TP53 can regulate tumor angiogenesis by unclear mechanisms. Here we show that p53 regulates hypoxic signaling through the transcriptional regulation of microRNA-107 (miR-107). We found that miR-107 is a microRNA expressed by human colon cancer specimens and regulated by p53. miR-107 decreases hypoxia...
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Full title
P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis
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TN_cdi_proquest_journals_201338129
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201338129
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0911082107
