Understanding and Exploiting the Mechanistic Basis for Selectivity of Polyketide Inhibitors of F0F1-...
Understanding and Exploiting the Mechanistic Basis for Selectivity of Polyketide Inhibitors of F0F1-ATPase
About this item
Full title
Author / Creator
Publisher
Washington: National Academy of Sciences of the United States of America
Journal title
Language
English
Formats
Publication information
Publisher
Washington: National Academy of Sciences of the United States of America
Subjects
More information
Scope and Contents
Contents
Recently, a family of polyketide inhibitors of F0F1-ATPase, including apoptolidin, ossamycin, and oligomycin, were shown to be among the top 0.1% most cell line selective cytotoxic agents of 37,000 molecules tested against the 60 human cancer cell lines of the National Cancer Institute. Many cancer cells maintain a high level of anaerobic carbon me...
Alternative Titles
Full title
Understanding and Exploiting the Mechanistic Basis for Selectivity of Polyketide Inhibitors of F0F1-ATPase
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_journals_201339659
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201339659
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.97.26.14766
