Estrogen Promotes the Survival and Pulmonary Metastasis of Tuberin-Null Cells
Estrogen Promotes the Survival and Pulmonary Metastasis of Tuberin-Null Cells
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Author / Creator
Yu, Jane J. , Robb, Victoria A. , Morrison, Tasha A. , Ariazi, Eric A. , Karbowniczek, Magdalena , Astrinidis, Aristotelis , Wang, Chunrong , Hernandez-Cuebas, Lisa , Seeholzer, Laura F. , Nicolas, Emmanuelle , Hensley, Harvey , Jordan, V. Craig , Walker, Cheryl L. , Henske, Elizabeth P. and Cobb, Melanie H.
Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Lymphangioleiomyomatosis (LAM) is an often fatal disease primarily affecting young women in which tuberin (TSC2)-null cells metastasize to the lungs. The mechanisms underlying the striking female predominance of LAM are unknown. We report here that 17-β-estradiol (E₂) causes a 3- to 5-fold increase in pulmonary metastases in male and female mice, r...
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Full title
Estrogen Promotes the Survival and Pulmonary Metastasis of Tuberin-Null Cells
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TN_cdi_proquest_journals_201345870
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201345870
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0810790106
