Histone Deacetylase Inhibitors Prevent Oxidative Neuronal Death Independent of Expanded Polyglutamin...
Histone Deacetylase Inhibitors Prevent Oxidative Neuronal Death Independent of Expanded Polyglutamine Repeats via an Sp1-Dependent Pathway
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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Oxidative stress is believed to be an important mediator of neurodegeneration. However, the transcriptional pathways induced in neurons by oxidative stress that activate protective gene responses have yet to be fully delineated. We report that the transcription factor Sp1 is acetylated in response to oxidative stress in neurons. Histone deacetylase...
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Histone Deacetylase Inhibitors Prevent Oxidative Neuronal Death Independent of Expanded Polyglutamine Repeats via an Sp1-Dependent Pathway
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TN_cdi_proquest_journals_201349755
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201349755
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0737363100
