Facilitated Replacement of Kupffer Cells Expressing a Paraoxonase-1 Transgene Is Essential for Ameli...
Facilitated Replacement of Kupffer Cells Expressing a Paraoxonase-1 Transgene Is Essential for Ameliorating Atherosclerosis in Mice
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Resident macrophages (i.e., Kupffer cells) are derived from hematopoietic stem cells (HSCs) and are primarily responsible for the removal from plasma of oxidized forms of low-density lipoprotein (LDL). The therapeutic potential of Kupffer cell expression of a transgene encoding paraoxonase-1 (PON1), whose plasma activity correlates with the protect...
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Full title
Facilitated Replacement of Kupffer Cells Expressing a Paraoxonase-1 Transgene Is Essential for Ameliorating Atherosclerosis in Mice
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TN_cdi_proquest_journals_201352579
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201352579
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0502677102
