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Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechan...

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechan...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201359968

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway

About this item

Full title

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway

Publisher

Washington: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (52), p.22468-22473

Language

English

Formats

Publication information

Publisher

Washington: National Academy of Sciences

More information

Scope and Contents

Contents

Sigma-1 receptors (Sig-1Rs) are endoplasmic reticulum (ER)-resident proteins known to be involved in learning and memory. Dendritic spines in hippocampal neurons play important roles in neuroplasticity and learning and memory. This study tested the hypothesis that Sig-1Rs might regulate denritic spine formation in hippocampal neurons and examined p...

Alternative Titles

Full title

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_journals_201359968

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201359968

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.0909089106

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