The 39-kDa Poly(ADP-Ribose) Glycohydrolase ARH3 Hydrolyzes O-Acetyl-ADP-Ribose, a Product of the Sir...
The 39-kDa Poly(ADP-Ribose) Glycohydrolase ARH3 Hydrolyzes O-Acetyl-ADP-Ribose, a Product of the Sir2 Family of Acetyl-Histone Deacetylases
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The silent information regulator 2 (Sir2) family of NAD-dependent N-acetyl-protein deacetylases participates in the regulation of gene silencing, chromatin structure, and longevity. In the Sir2catalyzed reaction, the acetyl moiety of N-acetyl-histone is transferred to the ADP-ribose of NAD, yielding O-acetyl-ADP-ribose and nicotinamide. We hypothes...
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Full title
The 39-kDa Poly(ADP-Ribose) Glycohydrolase ARH3 Hydrolyzes O-Acetyl-ADP-Ribose, a Product of the Sir2 Family of Acetyl-Histone Deacetylases
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TN_cdi_proquest_journals_201361049
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_201361049
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0607911103
